Role of Ghrelin in gastric cancer
10.16352/j.issn.1001-6325.2024.10.1460
- VernacularTitle:Ghrelin在胃癌中的作用
- Author:
Weikang LI
1
;
Dongbao LI
;
Jiayu REN
;
Xiaotong SUN
;
Kaipeng DUAN
;
Jin ZHOU
Author Information
1. 江苏省苏州大学附属第一医院 普通外科,江苏 苏州 215006
- Keywords:
Ghrelin;
gastric cancer;
signaling pathway;
sarcopenia;
simulation therapy
- From:
Basic & Clinical Medicine
2024;44(10):1460-1464
- CountryChina
- Language:Chinese
-
Abstract:
Ghrelin is a newly discovered gastrointestinal peptide that is involved in regulating the body's growth,development and energy balance,and plays a key role in the occurrence and progression of malignant tumors,such as cell proliferation,migration,invasion,apoptosis,inflammatory response and vascular disease.Generate immune cell infiltration and so on.Ghrelin affects the progression of gastric cancer by activa-ting NF-κB/p65 and AMPK and other signaling pathways.Ghrelin not only assist in early screening of gastric cancer,but also function a new marker for predicting the prognosis and survival of gastric cancer patients.Ghrelin and its analogs have clinical application value in the treatment of gastric cancer-related syndromes such as cachexia or sarcopenia.
