Role of TERT in regulating mitochondrial oxidative stress in diseases
10.16352/j.issn.1001-6325.2024.10.1436
- VernacularTitle:TERT调控线粒体氧化应激在疾病中的作用
- Author:
Zongyuan TIAN
1
;
Zhan LI
;
Ruixia LIU
Author Information
1. 首都医科大学附属北京妇产医院/北京妇幼保健院 中心实验室,北京 100026
- Keywords:
telomerase reverse transcriptase(TERT);
oxidative stress;
reactive oxygen species;
ferroptosis;
autophagy
- From:
Basic & Clinical Medicine
2024;44(10):1436-1441
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress is the result of imbalance between the formation of reactive oxygen species(ROS)and antioxidant level.Mitochondria are important organelles regulating oxidative stress.Telomerase reverse transcriptase(TERT)not only in the nucleus to maintain telomerase activity and telomere length,but also reversibly transits to mitochondria.Improving the activity of oxidative respiratory chain of mitochondria to reduce the production of mito-chondrial reactive oxygen species(mtROS)and to activate GSH system as well as autophagy pathway to promote the clearance of mtROS are all important to down-regulate the level of mtROS,which will alleviate oxidative stress and damage and keep the REDOX balance of cells and the normal function of the body.
