Advances in the treatment of dental stem cells for Parkinson's disease

VernacularTitle:牙源性干细胞治疗帕金森病的研究进展
Author: Manshu YU ¹ ; Xiaomin ZHAO ; Mingyue QIU ; Chunran LIU ; Risu NA
Author Information

1. 内蒙古医科大学赤峰临床医学院赤峰市医院,内蒙古赤峰 024000
Keywords: dental pulp stem cell; stem cells from human exfoliated deciduous teeth; neurodegenerative disease; Parkinson's dis-ease; exosome
From: Basic & Clinical Medicine 2024;44(9):1298-1302
CountryChina
Language:Chinese
Abstract: Parkinson's disease(PD)is the second most common neurodegenerative disease,mainly due to the loss of dopaminergic neurons in the substantia nigra(SN)of the midbrain,resulting in motor dysfunction.Dental stem cells(DSCs)are derived from the cranial neural crest which can be easily harvested.DSCs coming from the cranial neural crest have excellent proliferation and differentiation ability,and can promote nerve repair and regeneration.DSCs can secrete new dopamine neurons and secrete a large number of neurotro-phic factors(NTFs)to improve the neural function,and also inhibit the neuroinflammatory response through immune modulation.DSCs can effectively alleviate the motor dysfunction in rats with PD and play an important role in R&D of regenerative medicine.