Progress of gastric cancer organoids in basic research and clinical application
10.16352/j.issn.1001-6325.2024.09.1219
- VernacularTitle:胃癌类器官在基础研究与临床应用中的进展
- Author:
Baoqing LIU
1
;
Rong HUANG
;
Yan LU
;
Kai LI
;
Ning ZHANG
;
Changzheng LIU
;
Wei SONG
Author Information
1. 中国医学科学院基础医学研究所 北京协和医学院基础学院 重大疾病共性机制研究全国重点实验室,北京 100005
- Keywords:
gastric cancer;
clinical treatment;
organoid;
tumor microenvironment
- From:
Basic & Clinical Medicine
2024;44(9):1219-1222
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer ranks fifth in global cancer mortality,which is highly aggressive and heterogeneous.How-ever,the research and treatment of gastric cancer is hindered by short of research models that may characterize the developmental properties of gastric cancer.Gastric cancer organoid is a multicellular three-dimensional structure de-veloped in vitro,which can mimic the structure and function of native gastric cancer.Gastric cancer organoids have great application potential and development prospects in establishing gastric cancer research models,mimicking the tumor microenvironment,high-throughput screening of drugs,discovering new therapeutic targets,predicting clinical therapeutic responses,and guiding individualized treatment.In this paper,the progress of gastric cancer or-ganoids in basic research and clinical application is reviewed aiming for promoting the progress of preclinical re-search and supporting the clinical treatment of gastric cancer.
