Organ-on-a-chip:a more promising in vitro model
10.16352/j.issn.1001-6325.2024.09.1202
- VernacularTitle:器官芯片——更具前景的体外模型
- Author:
Zhenli YANG
1
;
Yujia XIA
;
Yuqin LIU
Author Information
1. 中国医学科学院基础医学研究所 北京协和医学院基础学院 病理学系,北京 100005
- Keywords:
organ-on-a-chip;
organoid;
disease model
- From:
Basic & Clinical Medicine
2024;44(9):1202-1207
- CountryChina
- Language:Chinese
-
Abstract:
Traditional in vitro models have inevitable limitations and there are significant differences in assessing drug efficacy and side effects as compared to human trials.Organ-on-a-chip technology simulates human organs in a physiological environment and functional chip with a high fidelity physiological or pathophysiological level,offering great innovative prospects for drug development.This paper mainly introduces the research progress and application of organ chip from the perspective of various systems in vivo.At the same time,the limitations of the current devel-opment process of organ chip and the future development direction are proposed.
