Research progress of astrocyte phagocytosis in Alzheimer's disease

VernacularTitle:星形胶质细胞吞噬作用在阿尔茨海默病中的研究进展
Author: Xiaoli QIN ^{1
,

2
,

3} ; Linna ZHAO ; Rong FU ; Yuying GUO ; Shixin XU
Author Information

1. 天津中医药大学第一附属医院,天津 300193
2. 国家中医针灸临床医学研究中心,天津 300193
3. 天津中医药大学研究生院,天津 301617
Keywords: astrocytes; phagocytosis; Alzheimer's disease
From: Basic & Clinical Medicine 2024;44(8):1180-1184
CountryChina
Language:Chinese
Abstract: Astrocytes are heavily activated in Alzheimer's disease,engulfing damaged synapses,Aβ proteins,Tau proteins,apoptotic cells and other substrates.However,these substrates are difficult to degrade,accumulate as the disease progresses,and impair the phagocytosis of astrocytes.During phagocytosis,astrocytes recognize different substrates through a variety of phagocytosis receptors and partially degrade the substrates through degrad-ing enzymes and lysosomal pathways.The accumulation of Aβ and Tau proteins in astrocytes caused astrocyte im-mune and metabolic disorders,and Aβ toxicity changed after phagocytosis.In addition,astrocytes and microglia form a complementary pattern and cooperate to complete phagocytosis through interaction.Regulating the pathway of astrocyte phagocytosis and degradation is believed to be a potential novo therapeutic for clinical treatment of Alzheimer's disease.