CD27/CD70 and idiopathic pulmonary fibrosis
10.16352/j.issn.1001-6325.2024.08.1170
- VernacularTitle:CD27/CD70与特发性肺纤维化
- Author:
Yuncong XU
1
;
Jinxu ZHENG
Author Information
1. 江苏大学附属医院呼吸与危重症医学科,江苏镇江 212000
- Keywords:
idiopathic pulmonary fibrosis;
CD27/CD70 axis;
PI3K/AKT pathway
- From:
Basic & Clinical Medicine
2024;44(8):1170-1174
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis(IPF)is a chronic interstitial lung disease marked by the significant in-volvement of fibroblasts,macrophages and lymphocytes.The CD27/CD70 axis is pivotal in shaping the immune mi-croenvironment present in the fibrotic aeras of lungs.This mentioned interaction involves molecular pathways that work in tandem with lung immune cells,particularly exerting a suppressive influence in the early phases of pulmo-nary fibrosis.Consequently,the CD27/CD70 axis presents a promising new target for immunotherapy in IPF.
