Association of T helper cells and cytokines with abdominal obesity in Hashimoto's thyroiditis
10.16352/j.issn.1001-6325.2024.08.1120
- VernacularTitle:桥本甲状腺炎中辅助T细胞及其细胞因子与腹型肥胖相关
- Author:
ZYNAT JAZYRA
1
,
2
,
3
;
Suli LI
;
Kaidi ZHANG
;
Fuhui MA
;
Guoying MA
;
Yanying GUO
Author Information
1. 新疆糖尿病临床医学研究中心,新疆 乌鲁木齐 830001
2. 新疆内分泌糖尿病研究所,新疆 乌鲁木齐 830001
3. 新疆维吾尔自治区人民医院 内分泌科,新疆乌鲁木齐 830001
- Keywords:
Hashimoto's thyroiditis;
thyroglobulin antibody;
abdominal obesity;
waist circumference;
IL-4
- From:
Basic & Clinical Medicine
2024;44(8):1120-1125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between abdominal obesity and autoimmune thyroid disease in the view point of helper T cells and cytokines.Methods Clinical and laboratory data were collected from 108 pa-tients with Hashimoto's thyroiditis(HT)plus abdominal obesity and 122 patients of Hashimoto's thyroiditis without abdominal obesity who visited the People's Hospital of Xinjiang Uygur Autonomous Region and also from the control population.Abdominal circumference was measured,and patients in the HT patients were grouped according to whether they were abdominally obese or not.The thyroglobulin antibody(TgAb)and thyroid peroxidase antibody(TPOAb)were detected,and the ratio of helper T cells and related cytokines were detected by flow cytometry and enzyme-linked immunosorbent assay.Results The abdominal circumference of the TgAb-positive group was higher than that of the TgAb-negative group(P＜0.05).Correlation analysis suggested that abdominal circumference was significantly and positively correlated with TgAb and IL-4 but negatively correlated with Th1.After correcting for gender and age,and abdominal obesity and IL-4 were risk factors for TgAb antibody positivity OR=3.080(95％CI:1.022-9.284)and OR=1.296(95％CI:1.022-9.284),both with P＜0.05.Conclusions Abdominal obesity may be an influential factor in TgAb antibody positivity,with larger abdominal circumference having higher TgAb antibody titers,lower Th1 levels,and higher IL-4 levels.Visceral adiposity may exacerbate autoimmune dam-age of thyroid tissue by disruption of helper T cell pathway.
