Progress on the role of transketolase in occurrence and treatment of diabetes and its complications

VernacularTitle:转酮醇酶在糖尿病及其并发症发生和治疗中作用的研究进展
Author: Zeying WANG ¹ ; Zhi LIU ; Yu TAI ; Zhongbin YANG ; Yan SU
Author Information

1. 包头医学院生物化学与分子生物学教研室,内蒙古包头 014010
Keywords: transketolase; diabetes; metabolism; pentose phosphate pathway
From: Basic & Clinical Medicine 2024;44(7):1023-1028
CountryChina
Language:Chinese
Abstract: Transketolase(TKT)is an important enzyme that catalyzes the non-oxidative phase group transfer reac-tion of pentose phosphate pathway(PPP),and is involved in the metabolism of various energy substances in the body,such as glucose,ribose,nucleotides and lipids.TKT can reduce oxidative stress,inflammation,atheroscle-rosis,endothelial dysfunction and Tau protein phosphorylation by inhibiting advanced glycated end-produces(AGEs)produced by non-enzymatic glycosylation(NEG)of proteins and lipids in a high-glucose environment im-proving blood glucose,glucose tolerance and β cell function so to prevent and treat diabetes and its complications.This article reviews research progress on the mechanism of TKT in the treatment of diabetes mellitus and its compli-cations.