Antihypertensive drug-related gene polymorphisms in patients with primary hypertension in Guiyang region
10.16352/j.issn.1001-6325.2024.07.0979
- VernacularTitle:贵阳地区原发性高血压患者降压药物疗效相关基因的多态性
- Author:
Wenbing ZOU
1
;
Anxian WANG
;
Zhengyuan CAO
Author Information
1. 贵航贵阳医院 医学检验科 贵州 贵阳 550009
- Keywords:
Guiyang region;
antihypertensive drug;
genetic polymorphism;
medication guidance
- From:
Basic & Clinical Medicine
2024;44(7):979-983
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distribution bio-relationship of loci related antihypertensive drug efficacy in patients with essential hypertension(EH)in Guiyang region to support the development of clinical guidance for in-dividualized medication of hypertension patients in this region.Methods A total of 406 EH patients who visited the Cardiology Department of Guiyang Hospital from December 2020 to December 2021 were collected as the study sub-jects and ligase sequencing method was applied to detect 7 gene loci of antihypertensive drugs.The distribution of gene loci in EH patients of different genders and from different geographic regions was evaluated.Results The mu-tation frequencies of the seven genes,CYP2D6*10(c.100 C＞T),CYP2C9*3(c.1075 A＞C),ADRB1(c.1165 G＞C),AGTR1(c.1166 A＞C),ACE(I/D),NPPA(T2238C)and CYP3A5*3(A6986G)were 47.29%,5.91%,73.15%,6.65%,34.24%,0.49%,and 69.70%respectively;There was no significant difference in distribution frequency of hypertension drug related gene polymorphisms among different genders.Conclusions The distribution frequency of alleles in 7 antihypertensive drug efficacy related loci is not related to gender of patients.EH patients in Guiyang region are more sensitive to β-blockers and calcium antagonists,but less sensitive to other types of antihypertensive drugs.Therefore,the dose administered should be adjusted appropriately when using β-blockers and calcium antagonists.
