Mechanism of Panax notoginseng saponins in the prevention of thrombosis

VernacularTitle:三七总皂苷预防血栓的机制
Author: Peijuan LI ¹ ; Chunmei WANG ; Qian ZHAO
Author Information

1. 四川大学华西医院全科医学中心全科 (特需) 病房,四川成都 610041
Keywords: Panax notoginseng saponins; thrombosis; mechanism
From: Basic & Clinical Medicine 2024;44(7):912-915
CountryChina
Language:Chinese
Abstract: Panax notoginseng saponins(PNSs)as the extracted bioactive components of Panax notoginseng,have a long history of application in prevention of thrombosis.PNSs down-regulate the expression of inflammatory factors,promoting endothelial cell growth,up-regulating the expression of anticoagulants and vasodilators,and regulating endothelial cell function;With multiple targets at which PNSs inhibit platelet adhesion,release,and aggregation;PNSs maintain the activity of the fibrinolytic system by regulating the dynamic balance of tissue type plasminogen activators and inhibitors;PNSs reduce blood viscosity,improve red blood cell indicators,and inhibit thrombosis through multiple pathways.