Regulation of host immune function by gut microbiota-derived secondary bile acids
10.16352/j.issn.1001-6325.2024.06.0887
- VernacularTitle:肠道菌群代谢物次级胆汁酸调控宿主免疫功能
- Author:
Lingling YUE
1
;
Zihui WANG
;
Xiaoqin LI
;
Lifeng LI
;
Wancun ZHANG
;
Zhidan YU
Author Information
1. 郑州大学附属儿童医院 河南省儿童医院郑州儿童医院 郑州市儿童消化疾病重点实验室,河南 郑州 450018
- Keywords:
gut microbiota;
secondary bile acids;
immune regulation
- From:
Basic & Clinical Medicine
2024;44(6):887-891
- CountryChina
- Language:Chinese
-
Abstract:
Disturbances of gut microbiota may affect the balance of the host immune system.The metabolism of gut microbiota produces many bioactive molecules interacting with host,typically secondary bile acids(SBAs).SBAs are involved in regulating the energy metabolism and the expression of inflammatory response-related genes by bind-ing to membrane receptors and nuclear receptors,such as takeda G protein-coupled receptor(TGR5)and farnesol X receptor(FXR),which are essential for maintaining host immune homeostasis.
