Metabolic reprogramming in idiopathic pulmonary fibrosis
10.16352/j.issn.1001-6325.2024.06.0882
- VernacularTitle:代谢重编程在特发性肺纤维化发病中的作用
- Author:
Ran DUAN
1
;
Qingyuan LI
;
Tong FENG
Author Information
1. 成都医学院第一附属医院,四川 成都 610500
- Keywords:
idiopathic pulmonary fibrosis;
metabolic reprogramming;
glycolysis;
targeted therapy
- From:
Basic & Clinical Medicine
2024;44(6):882-886
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis is caused by repeated damage to the pulmonary alveolar epithelium,leading to abnormal epithelial-mesenchymal transition and myofibroblast production,resulting in the accumulation of extra cellular matrix and remodeling of the interstitium.Analogous to many tumor cells,pulmonary fibrosis in-volves metabolic reprogramming,encompassing alterations in carbohydrate,lipid,and amino acid metabolism.Notably,this reprogramming is marked by enhanced glycolysis,diminished fatty acid oxidation paired with augmented synthesis,and increased degradation of glutamine.Glycolysis efficiently and rapidly fulfills the en-ergy requirements for the proliferation of macrophages and fibroblasts during fibrotic development.Additionally,the reprogramming of amino acid metabolism in activated fibroblasts not only facilitates collagen synthesis but also intensifies myofibroblast activation by generating reactive oxygen species(ROS)during the production of hydroxyproline.
