Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs.
10.4142/jvs.2016.17.1.111
- Author:
Tamara PONCHON
1
;
Mariana LOPEZ MERLO
;
Marcela FAYA
;
Marcelo PRIOTTO
;
Claudio BARBEITO
;
Cristina GOBELLO
Author Information
1. Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata, Buenos Aires B 1900 AVW, Argentina. cgobello@fcv.unlp.edu.ar
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
canid;
contraception;
endocrine disruption;
genital tract;
neonatal
- MeSH:
Animals;
Animals, Newborn;
Clitoris/drug effects;
Dogs;
Epithelium/*drug effects;
Female;
Medroxyprogesterone Acetate/*pharmacology;
Organ Size/drug effects;
Random Allocation;
Sexual Maturation/drug effects;
Uterus/*drug effects
- From:Journal of Veterinary Science
2016;17(1):111-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all cases without significant differences in the area occupied by the glands per µm2 of endometrium nor in the height of the uterine epithelium.
