Electrical excitability and aldosterone secretion in the zona glomerulosa cells:the role of ion channels
10.16352/j.issn.1001-6325.2024.06.0753
- VernacularTitle:肾上腺皮质球状带细胞的电兴奋性与醛固酮分泌:离子通道的作用
- Author:
Xuefeng ZHANG
1
;
Changlong HU
Author Information
1. 复旦大学 生命科学学院,上海 200434
- Keywords:
zona glomerulosa cells;
electrical excitability;
aldosterone;
ion channels;
rosette structure
- From:
Basic & Clinical Medicine
2024;44(6):753-757
- CountryChina
- Language:Chinese
-
Abstract:
Aldosterone is a kind of steroid hormone produced by the zona glomerulosa(ZG)cells of the adre-nal cortex which plays a crucial regulatory role in fluid-electrolyte balance and blood pressure stability.Aldo-sterone biosynthesis is a calcium-dependent process,and ion channels play a key role in this process.Primary aldosteronism is closely related to mutations in ion channels.Recent studies have highlighted an intriguing rela-tionship between the unique rosette structure of ZG cells and their electrical excitability.Elucidating the con-nection between rosettes and ZG cell electrical excitability as well as aldosterone secretion leads to a deeper un-derstanding of the mechanisms regulating aldosterone secretion and may provide new insights into the pathogen-esis of primary aldosteronism.
