Immune microenvironment of pheochromocytomas and paragangliomas
10.16352/j.issn.1001-6325.2024.06.0742
- VernacularTitle:嗜铬细胞瘤/副神经节瘤免疫微环境
- Author:
Yue ZHOU
1
;
Anli TONG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院 内分泌科 国家卫生健康委员会内分泌重点实验室,北京 100730
- Keywords:
pheochromocytomas/paragangliomas;
metastatic pheochromocytomas/paragangliomas;
tumor immune microenvironment;
immune cell;
immune checkpoint
- From:
Basic & Clinical Medicine
2024;44(6):742-747
- CountryChina
- Language:Chinese
-
Abstract:
Pheochromocytomas/Paragangliomas(PPGLs)are rare neuroendocrine tumors with a high hereditary predisposition.The pseudo-hypoxic PPGLs dominated by SDHx mutations show a higher potential of metastasis.Ap-proximately 10%-17%of PPGLs develop metastasis and patients with metastatic diseases have restricted treatment options and a poor prognosis.Tumor immune microenvironment(TIME)plays a crucial role in the development and progression of tumors as well as predicting patients'prognosis and their response to immune checkpoint inhibitors.Several studies have initially characterized the immune landscape of PPGLs.This review focuses on the infiltration of immune cells,the expression of immune checkpoints in the TIME of PPGLs and their relationships with genetics and metastasis of tumors in order to better understand the mechanisms of tumor immune evasion in PPGLs and pro-vide insights to support novel treatment strategy for metastatic PPGLs.
