Research progress of microgravity effect on liver and colon
10.16289/j.cnki.1002-0837.2024.04011
- VernacularTitle:微重力对肝脏和结肠作用的研究进展
- Author:
Yan LU
1
,
2
;
Mingzhou GUO
;
Huikai LI
;
Qianqian CHEN
;
Xiaofeng QIU
;
Enqiang LINGHU
Author Information
1. 中国人民解放军总医院第一医学中心消化内科医学部,北京 100853
2. 中国人民解放军总医院京北医疗区,北京 100094
- Keywords:
microgravity;
weightlessness;
space flight;
the digestive system;
liver;
colon
- From:Space Medicine & Medical Engineering
2024;35(4):268-272
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing maturity and progress of China's space technology,astronauts can stay longer in the space station and complete more complex space experiments and tasks.In the Microgravity(MG)environment of space,the digestive system of astronauts is inevitably affected,especially the liver and colon,and there are many physiological and pathological changes.MG can affect liver metabolic function,cell proliferation and differentiation,oxidative stress response and inflammatory factor levels.MG can disrupt the intestinal barrier of the colon,intestinal flora and microecology,intestinal immunity,and the gut-liver axis.However,the existing studies on the effects of MG on liver and colon are not completely clear,and there is a lack of reliable diagnostic indicators for the pathological changes of both.Therefore,in order to explore the damage mechanism of MG on liver and colon and ensure the digestive system health of astronauts,this paper reviews the research progress on the effects of MG on liver and colon.
