Mitochondria-The intracellular receptors for spatial microgravity
10.16289/j.cnki.1002-0837.2024.04010
- VernacularTitle:线粒体——空间微重力的细胞内感受器
- Author:
Lerong CHEN
1
;
Pengxiao WANG
;
Zhen WANG
;
Jiangang LONG
Author Information
1. 西安交通大学生命科学与技术学院,生物医学信息工程教育部重点实验室,线粒体生物医学研究所,西安 710049
- Keywords:
microgravity;
simulated microgravity;
mitochondria;
metabolic regulation
- From:Space Medicine & Medical Engineering
2024;35(4):258-267
- CountryChina
- Language:Chinese
-
Abstract:
The weightlessness effect during space flight can cause damage to the astronaut's body,and this damage requires a longer recovery time even after the astronaut returns to Earth,and even irreversible damage may occur.Mitochondria are important organelles within cells,participating in regulating a range of important physiological and biochemical processes.Mitochondrial mediated metabolic regulation can sense microgravity stress,which is an early intracellular response caused by microgravity,promoting the adaptation of intracellular metabolism and stress-induced damage.This article reviews the research progress on the effects and related mechanisms of microgravity and simulated microgravity on cell mitochondria,providing a theoretical basis for the development of protection strategies targeting mitochondria.
