Aerobic exercise modulates changes in cardiac function due to simulated weightlessness through the AMPK/ULK1/Beclin1 pathway
10.16289/j.cnki.1002-0837.2024.04006
- VernacularTitle:有氧运动通过AMPK/ULK1/Beclin1通路调节模拟失重导致的心脏功能变化的研究
- Author:
Yequn LIU
1
;
Jianjun YANG
;
Min YANG
;
Hongli LI
;
Fudong GAO
;
Yuxuan HUANG
;
Shuling ZHANG
;
Junzhi SUN
Author Information
1. 成都体育学院运动医学与健康学院,成都 610041
- Keywords:
spaceflight;
cardiac function;
AMPK;
ULK1;
beclin1
- From:Space Medicine & Medical Engineering
2024;35(4):235-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible mechanisms of myocardial injury induced by simulated weightlessness in space flight and the recovery of myocardium in rats by aerobic exercise intervention.Methods The body weight of rats was weighed using an electronic balance;the cardiac function indexes of rats in each group were detected using echocardiography and isolated cardiac perfusion;and the expression of proteins related to the AMPK/ULK1/Beclin1 pathway in the myocardial tissues of rats in each group was detected using Western Blot.Results(1)When compared with the C1 group,the T1 group not statistically significant in body weight(P?>?0.05),and the wet weight of the flounder muscle,the wet weight-to-weight ratio of the flounder muscle,and the heart weight were all significantly decreased(P??0.05).After 4 weeks of aerobic exercise,when compared to group C2,group R showed a significant rise in the expression of AMPK and ULK1(P??0.05),and a rise in the expression of Beclin1,but not statistically significant(P?>?0.05);and group A showed a slight increase in the expression of AMPK,ULK1 and Beclin1 expression decreased slightly but not statistically significant(P?>?0.05),p-AMPK expression decreased significantly(P??0.05),and a significant decrease in the expression of ULK1(P??0.05);the expression of p-ULK1 decreased significantly(P?
