Two-sample Mendelian randomization analysis of causal relationship between eczema and autoimmune diseases
10.11817/j.issn.1672-7347.2024.240103
- VernacularTitle:双样本孟德尔随机化分析湿疹与自身免疫性疾病之间的因果关系
- Author:
Chunli CHEN
1
;
Siyu YAN
;
Bangbei WAN
;
Yangyiyi YU
;
Jinrong ZENG
;
Lina TAN
;
Jianyun LU
Author Information
1. 中南大学湘雅三医院皮肤科,长沙 410013
- Keywords:
eczema;
atopic eczema;
autoimmune diseases;
Crohn's disease;
ulcerative colitis;
Mendelian randomization
- From:
Journal of Central South University(Medical Sciences)
2024;49(6):932-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The causal relationship between eczema and autoimmune diseases has not been previously reported.This study aims to evaluate the causal relationship between eczema and autoimmune diseases. Methods:The two-sample Mendelian randomization(MR)method was used to assess the causal effect of eczema on autoimmune diseases.Summary data from the Genome-Wide Association Study Catalog(GWAS)were obtained from the Integrative Epidemiology Unit(IEU)database.For eczema and autoimmune diseases,genetic instrument variants(GIVs)were identified according to the significant difference(P＜5×10-8).Causal effect estimates were generated using the inverse-variance weighted(IVW)method.MR Egger,maximum likelihood,MR-PRESSO,and MR-RAPS methods were used for alternative analyses.Sensitivity tests,including heterogeneity,horizontal pleiotropy,and leave-one-out analyses,were performed.Finally,reverse causality was assessed. Results:Genetic susceptibility to eczema was associated with an increased risk of Crohn's disease(OR=1.444,95％CI 1.199 to 1.738,P＜0.001)and ulcerative colitis(OR=1.002,95％CI 1.001 to 1.003,P=0.002).However,no causal relationship was found for the other 6 autoimmune diseases,including systemic lupus erythematosus(SLE)(OR=0.932,P=0.401),bullous pemphigoid(BP)(OR=1.191,P=0.642),vitiligo(OR=1.000,P=0.327),multiple sclerosis(MS)(OR=1.000,P=0.965),ankylosing spondylitis(AS)(OR=1.001,P=0.121),rheumatoid arthritis(RA)(OR=1.000,P=0.460).Additionally,no reverse causal relationship was found between autoimmune diseases and eczema. Conclusion:Eczema is associated with an increased risk of Crohn's disease and ulcerative colitis.No causal relationship is found between eczema and SLE,MS,AS,RA,BP,or vitiligo.
