Hypercoagulable state and risk of venous thromboembolism in Cushing syndrome
10.11817/j.issn.1672-7347.2024.230575
- VernacularTitle:库欣综合征高凝状态与静脉血栓栓塞风险
- Author:
Yuke LIU
1
;
Yu TANG
;
Huiwen TAN
;
Jianwei LI
Author Information
1. 四川大学华西医院内分泌代谢科,垂体瘤及相关疾病诊疗中心,成都 610041
- Keywords:
Cushing syndrome;
hypercoagulable state;
venous thromboembolism
- From:
Journal of Central South University(Medical Sciences)
2024;49(6):825-831
- CountryChina
- Language:Chinese
-
Abstract:
Cushing syndrome(CS)is an endocrine-metabolic disorder characterized by hypercortisolism.Elevated cortisol levels can induce a hypercoagulable state,increasing the risk of venous thromboembolism(VTE).Both pituitary-origin Cushing disease(CD)and adrenal-origin non-adrenocorticotropic hormone(ACTH)-dependent CS are primarily treated with surgery.The dual impact of surgery and the underlying disease further elevates the risk of VTE,potentially leading to pulmonary embolism,which poses a severe threat to patient survival.Additionally,CS patients in a hypercoagulable state have a higher incidence of cardiovascular diseases and VTE,and even mortality compared with the general population.Untreated active CS patients have a 17.8-fold increased risk of VTE compared to the general population.In recent years,the relationship between the hypercoagulable state in CS and VTE has garnered increasing attention from clinicians.A better understanding of the clinical epidemiological characteristics,pathophysiological mechanisms,and clinical prevention and treatment of VTE and pulmonary embolism in CS can provide valuable references for the standardized use of prophylactic anticoagulant therapy in CS patients.
