A case of angioedema associated with losartan.
- Author:
Min Cheul KIM
1
;
Jong Su KIM
;
Jae Wook CHUNG
;
Hyun Ju SONG
;
Jeong Hee CHOI
;
Yu Jin SUH
;
Chang Hee SUH
;
Dong Ho NAHM
;
Hae Sim PARK
Author Information
1. Department of Allergy and Rheumatology, Ajou Univeraity School of Medicine, Suwon, Korea. hspark@madang.ajou.ac.kr
- Publication Type:Case Report
- Keywords:
Angioedema;
angiotensin II receptor blocker
- MeSH:
Angioedema*;
Angiotensin I;
Angiotensin II;
Angiotensin-Converting Enzyme Inhibitors;
Anti-Inflammatory Agents, Non-Steroidal;
Aspirin;
Bradykinin;
Cough;
Edema;
Hereditary Angioedema Types I and II;
Humans;
Losartan*;
Membranes;
Mucus;
Penicillins;
Receptors, Angiotensin;
Skin
- From:Journal of Asthma, Allergy and Clinical Immunology
2003;23(1):95-98
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Angioedema is a non-pitting edema that occurs in the skin and mucus membranes. It is known that major etiologies include hereditary deficiency of C1 esterase inhibitor, temperature extreme, trauma, food sensitivity, and medications such as penicillin, aspirin, NSAIDS and ACE inhibitors. ACE inhibitors are blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and increasing local levels of bradykinin, a potent vasodilator. This increased bradykinin has been theorized to cause angioedema and cough in patients on ACE inhibitors. However, there has been very few causes of angioedema induced by angiotensin II receptor blocker. This is the first report of a patient presenting angioedema induced by losartan -angiotensin II receptor blocker- in this century.
