Prenatal ultrasound diagnosis and quality control of fetal nuchal translucency
10.11817/j.issn.1672-7347.2024.240005
- VernacularTitle:胎儿颈项透明层产前超声诊断及质量控制
- Author:
Xiaohua YUAN
1
;
Yimei FU
Author Information
1. 中南大学湘雅医院产科超声影像室,长沙 410008
- Keywords:
fetal nuchal translucency;
quality control;
prenatal ultrasound diagnosis;
structural screening;
chromosomal abnormalities
- From:
Journal of Central South University(Medical Sciences)
2024;49(4):603-610
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In clinical ultrasound examinations,it is challenging to perform quality control on the images of each fetal nuchal translucency(NT)and crown-rump length(CRL).However,small measurement differences can increase the probability of false-positive or false-negative diagnosis.Therefore,it is necessary to establish a quality control system for fetal NT examination.This study aims to control the quality of fetal NT and CRL measurements,evaluate the accuracy of ultrasound physicians in early pregnancy NT measurements,and analyze the impact of increased fetal structure screening on the detection rate of chromosomal abnormalities. Methods:Data were collected from cases before and after 12 months of NT examination quality control,with 2 214 before quality control and 2 538 cases after quality control.Three quality control data metrics were analyzed:NT multiple of median(NT-MoM),standard deviation(SD)of log10MoM[(SD)log10MoM],and the slope of NT on CRL(SNC).The performance of NT measurements was monitored through the individual CRL NT-MoM within the 0.9-1.1 MoM range of the normal median curve,while grouped based on different years of experience(＜3 years,3-6 years,＞6 years),and NT-MoM values among these groups were compared.Data on NT thickening,structural anomalies,and chromosomal abnormalities were retrospectively analyzed during the quality control period. Results:According to the curve equation of the American NTQR project group,the NT-MoM value before quality control was 0.921 7 MoM,the(SD)log10MoM value was 0.091 92,and the SNC value was 12.20％.After quality control,the NT-MoM value was 0.948 3 MoM,the(SD)log10MoM value was 0.094 81,and the SNC value was 11.43％.The comparison of NT-MoM values before and after quality control showed a statistically significant difference(P＜0.000 1).The comparison of NT-MoM values measured by ultrasound physicians with different years of experience before and after quality control also showed statistically significant differences(P＜0.000 1).The NT-MoM values for the 3-6 years and＞6 years groups were higher after quality control(P＜0.05),while the＜3 years group showed no significant difference before and after quality control(P＞0.05).After quality control,cases of NT thickening without significant structural abnormalities accounted for 19.05％,NT thickening with structural abnormalities accounted for 47.62％,and NT normal with structural abnormalities accounted for 33.33％.There were 36 cases of fetal heart abnormalities,accounting for 20.34％of the total abnormality rate,with a positive rate of 36％in chromosome tests. Conclusion:After quality control,ultrasound physicians measure NT more accurately,but differences among measurements remain.Measurements by experienced ultrasound physicians are closer to expected values,usually lower than expected.Monitoring fetal NT and CRL measurements helps improve measurement accuracy.Increasing structural screening during NT examinations,especially for the fetal heart,enhances the detection rate of chromosomal abnormalities.
