Effect of Hb conformational changes on oxygen transport physiology

VernacularTitle:Hb构象变化对氧转运生理功能的影响
Author: Ziyue YIN ^{1
,

2} ; Doudou LI ; Qianwen GUO ; Rong WANG ; Wenbin LI
Author Information

1. 甘肃中医药大学药学院,兰州 730050
2. 中国人民解放军联勤保障部队第九四〇医院全军高原医学实验室,兰州 730050
Keywords: hemoglobin; conformational regulators; oxygen affinity; anti-hypoxia
From: Journal of Central South University(Medical Sciences) 2024;49(3):467-475
CountryChina
Language:Chinese
Abstract: Red blood cells(RBCs)are the primary mediators of oxygen transport in the human body,and their function is mainly achieved through conformational changes of hemoglobin(Hb).Hb is a tetramer composed of four subunits,with HbA being the predominant Hb in healthy adults,existing in two forms:tense state(T state)and relaxed state(R state).Endogenous regulators of Hb conformation include 2,3-diphosphoglyceric acid,carbon dioxide,protons,and chloride ions,while exogenous regulators include inositol hexaphosphate,inositol tripyrophosphate,benzabate,urea derivative L35,and vanillin,each with different mechanisms of action.The application of Hb conformational regulators provides new insights into the study of hypoxia oxygen supply issues and the treatment of sickle cell disease.