Mechanisms and treatment of anemia related to cardiac arrest
10.11817/j.issn.1672-7347.2024.230497
- VernacularTitle:心脏骤停后相关性贫血的机制及治疗
- Author:
Xiang PENG
1
;
Xiaoye MO
;
Xiangmin LI
Author Information
1. 中南大学湘雅医院急诊科,长沙 410008
- Keywords:
cardiac arrest;
anemia;
oxidative stress/inflammatory response;
hepcidin;
gastrointestinal ischemic injury
- From:
Journal of Central South University(Medical Sciences)
2024;49(3):457-466
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac arrest is a common and fatal emergency situation.Recently,an increasing number of studies have shown that anemia in patients with cardiac arrest is closely related to high mortality rates and poor neurological outcomes.Anemia is prevalent among patients with post-cardiac arrest syndrome(PCAS),but its specific pathogenesis remains unclear.The mechanisms may involve various factors,including reduced production of erythropoietin,oxidative stress/inflammatory responses,gastrointestinal ischemic injury,hepcidin abnormalities,iatrogenic blood loss,and malnutrition.Measures to improve anemia related to cardiac arrest may include blood transfusions,administration of erythropoietin,anti-inflammation and antioxidant therapies,supplementation of hematopoietic materials,protection of gastrointestinal mucosa,and use of hepcidin antibodies and antagonists.Therefore,exploring the latest research progress on the mechanisms and treatment of anemia related to cardiac arrest is of significant guiding importance for improving secondary brain injury caused by anemia and the prognosis of patients with cardiac arrest.
