Research progress in the role of gut microbiota in acute kidney injury
10.11817/j.issn.1672-7347.2024.230526
- VernacularTitle:肠道菌群在急性肾损伤中作用的研究进展
- Author:
Tianxiao CHEN
1
;
Chang CHANG
;
Bao HOU
;
Liying QIU
;
Haijian SUN
;
Xuexue ZHU
Author Information
1. 江南大学无锡医学院基础医学系,江苏 无锡 214122
- Keywords:
acute kidney injury;
gut microbiota;
inflammation;
toxins;
short-chain fatty acids;
probiotic;
postbiotics;
traditional Chinese medicine
- From:
Journal of Central South University(Medical Sciences)
2024;49(3):385-391
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury(AKI)remains a global public health problem with high incidence,high mortality rates,expensive medical costs,and limited treatment options.AKI can further progress to chronic kidney disease(CKD)and eventually end-stage renal disease(ESRD).Previous studies have shown that trauma,adverse drug reactions,surgery,and other factors are closely associated with AKI.With further in-depth exploration,the role of gut microbiota in AKI is gradually revealed.After AKI occurs,there are changes in the composition of gut microbiota,leading to disruption of the intestinal barrier,intestinal immune response,and bacterial translocation.Meanwhile,metabolites of gut microbiota can exacerbate the progression of AKI.Therefore,elucidating the specific mechanisms by which gut microbiota is involved in the occurrence and development of AKI can provide new insights from the perspective of intestinal microbiota for the prevention and treatment of AKI.
