Molecular mechanisms of ferroptosis and its effects on bladder cancer
10.11817/j.issn.1672-7347.2024.230352
- VernacularTitle:铁死亡的分子机制及其对膀胱癌的影响
- Author:
Ruijie LI
1
,
2
;
Yiping NING
;
Yacheng YUAN
;
Xukai YANG
Author Information
1. 甘肃中医药大学第一临床医学院,兰州 730000
2. 中国人民解放军联勤保障部队第九四〇医院泌尿外科,兰州 730050
- Keywords:
bladder cancer;
ferroptosis;
lipid peroxidation;
phospholipid metabolism;
iron metabolism;
Xc-/glutathione/glutathione peroxidase 4;
ferroptosis relevant molecules
- From:
Journal of Central South University(Medical Sciences)
2024;49(2):286-295
- CountryChina
- Language:Chinese
-
Abstract:
Bladder cancer(BC)is one of the 3 common malignant tumors in the urinary system,with high incidence,easy metastasis,poor therapeutic efficacy,and poor prognosis,which seriously threatens the health of human.Tumor cells exhibit a strong demand for iron,and iron overload can induce ferroptosis,which is an iron dependent cell death caused by lipid peroxidation and cell membrane damage.Therefore,ferroptosis has strong anti-tumor potential.The molecular mechanisms of ferroptosis is associated with abnormalities in cellular phospholipid metabolism and iron metabolism,and dysregulation of antioxidant and non-antioxidant systems Xc-/glutathione(GSH)/glutathione peroxidase 4(GPX4).Ferroptosis relevant molecules play important roles in the occurrence and development,metastasis,drug resistance,and immune response of BC,and are expected to become targets for the treatment of BC.
