Development History and Frontier Research Progress of Pharmacokinetics of Traditional Chinese Medicine
10.13359/j.cnki.gzxbtcm.2024.10.034
- VernacularTitle:中药药代动力学发展史和前沿研究进展
- Author:
Li-Jun ZHU
1
;
Zhuo-Ru HE
;
Cai-Yan WANG
;
Dan-Yi LU
;
Jun-Ling YANG
;
Wei-Wei JIA
;
Chen CHENG
;
Yu-Tong WANG
;
Liu YANG
;
Zhi-Peng CHEN
;
Bao-Jian WU
;
Rong ZHANG
;
Chuan LI
;
Zhong-Qiu LIU
Author Information
1. 广州中医药大学,广东广州 510006
- Keywords:
pharmacokinetics of TCM;
history of development;
frontier;
research progress
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(10):2746-2757
- CountryChina
- Language:Chinese
-
Abstract:
Pharmacokinetics of traditional Chinese medicine(TCM)is a discipline that adopts pharmacokinetic research methods and techniques under the guidance of TCM theories to elucidate the dynamic changes in the absorption,distribution,metabolism and excretion of active ingredients,active sites,single-flavour Chinese medicinal and compounded formulas of TCM in vivo.However,the sources and components of TCM are complex,and the pharmacodynamic substances and mechanisms of action of the majority of TCM are not yet clear,so the pharmacokinetic study of TCM is later than that of chemical medicines,and is far more complex than that of chemical medicines,and its development also confronts with challenges.The pharmacokinetic study of TCM originated in the 1950s and has experienced more than 70 years of development from the initial in vivo study of a single active ingredient,to the pharmacokinetic and pharmacodynamic study of active ingredients,to the pharmacokinetic study of compound and multi-component of Chinese medicine.In recent years,with the help of advanced extraction,separation and analysis technologies,gene-editing animals and cell models,multi-omics technologies,protein purification and structure analysis technologies,and artificial intelligence,etc.,the pharmacokinetics of TCM has been substantially applied in revealing and elucidating the pharmacodynamic substances and mechanisms of action of Chinese medicines,research and development of new drugs of TCM,scientific and technological upgrading of large varieties of Chinese patent medicines,as well as guiding the rational use of medicines in clinics.Pharmacokinetic studies of TCM have made remarkable breakthroughs and significant development in theory,methodology,technology and application.In this paper,the history of the development of pharmacokinetics of TCM and the progress of cutting-edge research was reviewed,with the aim of providing ideas and references for the pharmacokinetics of TCM and related research.
