A Case of Generalized Pustular Psoriasis Associated with Myasthenia Gravis.
- Author:
Jeong Ho RYU
1
;
Hyun Jin JEON
;
Hyeong Don BANG
;
Kwang Ho KIM
;
Kwang Joong KIM
Author Information
1. Department of Dermatology, College of Medicine, Hallym University, Seoul, Korea. dr-rjh@hanmail.net
- Publication Type:Case Report
- Keywords:
Generalized pustular psoriasis;
Myasthenia gravis
- MeSH:
Acitretin;
Autoimmune Diseases;
Cyclosporine;
Humans;
Male;
Middle Aged;
Myasthenia Gravis*;
Pregnancy;
Psoriasis*;
Solar System
- From:Korean Journal of Dermatology
2003;41(3):367-370
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Generalized pustular psoriasis(GPP) is an uncommon and severe form of psoriasis. The possible provocative factors such as steroid therapy, infection, stress, drugs, pregnancy, sun exposure, and metabolic disorders were reported. Among them, corticosteroid therapy is thought to be the most common factor. Although the cause of psoriasis remain obscure, the coexistence of psoriasis and autoimmune disease and cyclosporin accepted for the treament of psoriasis emphasize the importance of immunologic mechanism in the pathogenesis of psoriasis. We present a case of GPP in a 48-year-old male, who has had a history of myasthenia gravis since the age of 34 years and managed with long-term corticosteroid therapy. With the administration of acitretin and cyclosporin, generalized pustular eruptions nearly cleared and clinical improvement was achieved.
