Exploration of Traditional Chinese Medicine Interventions for Inflammation-to-Tumor Transition in Cervical High-Risk Human Papillomavirus Infection from the Perspective of Damp-Heat Accumulation Resulting into Toxin
10.13359/j.cnki.gzxbtcm.2024.09.036
- VernacularTitle:基于"湿热蕴毒"探讨宫颈高危型人乳头瘤病毒感染"炎-癌转化"的中医药干预思路
- Author:
Yu-Xi MIAO
1
;
Gen-Ping ZENG
;
Pei-Yin LI
;
Xi-Jing LU
;
Song-Ping LUO
;
Lei ZENG
Author Information
1. 广州中医药大学,广东广州 510405
- Keywords:
human papillomavirus(HPV);
inflammation-to-tumor transition;
cervical cancer;
inflammation;
damp-heat;
spleen deficiency and liver depression;
cancer toxin;
clearing heat and drying dampness;
strengthening the spleen and soothing the liver
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(9):2472-2478
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation-to-tumor transition is one of the important mechanisms by which the cervical high-risk human papillomavirus(HR-HPV)infection develops into cervical cancer.Persistent cervical HR-HPV infection is an important cause of cervical cancer,and the focal uncontrolled inflammatory microenvironment caused by persistent cervical HR-HPV infection is the underlying mechanism of cervical cancer.The macroscopic and microscopic pathological process of inflammation-to-tumor transition is consistent with the pathogenesis evolution of damp-heat accumulation resulting into toxin in traditional Chinese medicine(TCM):the accumulation of damp-heat is the driving factor of inflammation-to-tumor transition,long-term retention of damp-heat leading to spleen deficiency and liver depression contributes to the characteristics of pathogenesis evolution,and long-term retention of damp-heat toxin causes the disorder of liver and spleen and then blood stasis accumulates in the cervical orifice,which eventually becomes cancer toxin.The process of inflammation-to-tumor transition caused by persistent cervical HR-HPV infection is due to the pathological factors of damp,heat,deficiency and toxin in TCM.Therefore,the regulation of inflammatory microenvironment caused by persistent cervical HR-HPV infection is the key approach to the prevention and treatment of cervical cancer.For the treatment of cervical cancer,methods of clearing heat and drying dampness,strengthening the spleen and soothing the liver are the key therapies.By intervention with the proper pathogen-eliminating methods and with simultaneous regulation of the interior and exterior,the process of inflammation-to-tumor transition can be interrupted.The exploration of inflammation-to-tumor transition caused by persistent cervical HR-HPV infection from the perspective of damp-heat accumulation resulting into toxin will provide thoughts for the prevention and treatment of cervical cancer with TCM and for Chinese medicine in intervening inflammation-to-tumor transition.
