Research Progress in Ferroptosis and Osteoporosis,and the Prevention and Treatment of Osteoporosis by Chinese Medicine Through Ferroptosis Mechanism
10.13359/j.cnki.gzxbtcm.2024.07.041
- VernacularTitle:铁死亡与骨质疏松症及中医药通过铁死亡机制防治骨质疏松症的研究进展
- Author:
Wei XIE
1
,
2
;
Gao-Xiang WANG
;
Yu-Xin YAN
;
Shu-Fang CHU
;
De-Liang LIU
;
Xue-Mei LIU
Author Information
1. 广州中医药大学第四临床医学院,广东深圳 518000
2. 深圳市中医院,广东深圳 518000
- Keywords:
osteoporosis;
ferroptosis;
iron overload;
lipid peroxidation;
reactive oxygen species;
Achyranthis Bidentatae Radix;
icariin;
gastrodin;
Chinese medicine;
review
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(7):1931-1936
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new type of programmed cell death different from apoptosis and necrosis.Its mechanism involves iron overload,lipid peroxidation,and reactive oxygen species(ROS)generation caused by disordered iron metabolism.Ferroptosis is associated with primary osteoporosis as well as the secondary osteoporosis such as steroid-induced osteoporosis,diabetic osteoporosis and postmenopausal osteoporosis.The Chinese medicines for the prevention and treatment of osteoporosis through the mechanism of ferroptosis mainly involve Chinese herbal compounds such as herbal pair of Eucommiae Cortex-Dipsaci Radix,Jintiange Capsules,and Bugu Shengsui Prescription,the single Chinese herbal medicine of Achyranthis Bidentatae Radix,and the active ingredients of herbal medicines such as icariin,gastrodin,quercetin,and artesunate.The prevention and treatment of osteoporosis by Chinese medicine monomer and Chinese herbal compound can inhibit ferroptosis through multiple targets and multiple pathways.At present,Chinese medicine has advantages in the prevention and treatment of postmenopausal osteoporosis.The prevention and treatment of osteoporosis by regulating the mechanism of ferroptosis can provide a direction for the future research on the prevention and treatment of osteoporosis by Chinese medicine.
