Clinical Observation of Xiaoying Sanjie Granules in the Treatment of Benign Thyroid Nodules with Qi Stagnation and Phlegm Obstruction Type
10.13359/j.cnki.gzxbtcm.2024.07.014
- VernacularTitle:消瘿散结颗粒治疗气郁痰阻型良性甲状腺结节的临床疗效观察
- Author:
Yu-Xi ZHOU
1
;
Tao-Qing YIN
;
Shuai XU
;
Jun-Wei WU
;
Ren-Qun YE
Author Information
1. 广州中医药大学第七临床医学院,广东深圳 518133
- Keywords:
Xiaoying Sanjie Granules;
Sini San;
Banxia Houpo Decoction;
qi stagnation and phlegm obstruction type;
thyroid nodules
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(7):1750-1756
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and safety of Xiaoying Sanjie Granules(derived from the modified Sini San and Banxia Houpo Decoction)in the treatment of patients with benign thyroid nodules of qi stagnation and phlegm obstruction type.Methods A retrospective study was conducted.According to the treatment methods,60 patients with benign thyroid nodules of qi stagnation and phlegm obstruction type were divided into observation group and control group,30 cases in each group.The control group was given health training alone,and the observation group was given oral use of Xiaoying Sanjie Granules on the basis of treatment for the control group.The course of treatment covered 12 weeks.The changes of traditional Chinese medicine(TCM)syndrome scores,maximum cross-section diameter of the thyroid nodule and thyroid function indexes of thyroid stimulating hormone(TSH),free triiodothyronine(FT3)and free thyroxine(FT4)in the two groups before and after treatment were observed.After treatment,the clinical efficacy and adverse reactions were compared between the two groups.Results(1)After 12 weeks of treatment,the total effective rate of the observation group was 73.33%(22/30),and that of the control group was 10.00%(3/30).The intergroup comparison(tested by chi-square test)showed that the efficacy of the observation group was significantly superior to that of the control group(P＜0.01).(2)After treatment,the TCM syndrome scores of the observation group were significantly lower than those before treatment(P＜0.01),and the maximum cross-section diameter of the thyroid nodule was significantly smaller than that before treatment(P＜0.01).However,no obvious improvement of TCM syndromes and the maximum cross-section diameter of the thyroid nodule was presented in the control group(P＞0.05).The intergroup comparison showed that the decrease of TCM syndrome scores and the reduction of the maximum cross-section diameter of the thyroid nodule in the observation group were significantly superior to those in the control group(P＞0.05).(4)During the treatment,no obvious adverse reactions occurred in the two groups,indicating high safety.Conclusion Xiaoying Sanjie Granules exerts certain effects on patients with benign thyroid nodules of qi stagnation and phlegm obstruction type.The granuels are effective on significantly reduce the maximum cross-section diameter of the thyroid nodule,improve the clinical symptoms of patients,and has fewer adverse reactions,with high safety.
