Observation on Clinical Efficacy of Therapy of Clearing Heat,Percolating Dampness and Lowering Turbidity Combined with Silibin Meglumine Tablets in the Treatment of Non-alcoholic Steatohepatitis of Damp-Heat Accumulation Type
10.13359/j.cnki.gzxbtcm.2024.07.013
- VernacularTitle:清热渗湿降浊法联合水飞蓟宾葡甲胺片治疗湿热蕴结型非酒精性脂肪性肝炎临床疗效观察
- Author:
Hua-Lu FU
1
;
Huo-Cheng YE
;
Zi-Chen OUYANG
;
Yan-Ping LU
;
Shu LI
;
Jing-Bao HU
Author Information
1. 广州中医药大学附属宝安中医院,广东深圳 518100
- Keywords:
therapy of clearing heat,percolating dampness and lowering turbidity;
non-alcoholic steatohepatitis(NASH);
damp-heat accumulation type;
liver function;
alanine aminotransferase(ALT);
blood lipid;
degree of hepatic steatosis
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(7):1744-1750
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of therapy of clearing heat,percolating dampness and lowering turbidity combined with Silibin Meglumine Tablets in the treatment of non-alcoholic steatohepatitis(NASH)patients with abnormal alanine aminotransferase(ALT)level of damp-heat accumulation type.Methods A retrospective study was conducted.According to the medication,80 patients with NASH with abnormal ALT level of damp-heat accumulation type were divided into control group and observation group,with 40 cases in each group.The control group was treated with Silibin Meglumine Tablets,and the observation group was treated with therapy of clearing heat,percolating dampness and lowering turbidity on the basis of treatment for the control group.The course of treatment covered 12 weeks.The changes of liver function indicators of ALT,aspartate aminotransferase(AST),and gamma glutamyl transpeptidase(GGT),blood lipid indicators of total cholesterol(CHOL)and triglyceride(TRIG),and the degree of hepatic steatosis in the two groups were observed before and after treatment.After treatment,the clinical efficacy and safety of the two groups were evaluated.Results(1)After 12 weeks of treatment,the total effective rate of the observation group was 95.00%(38/40),and that of the control group was 77.50%(31/40).The curative effect of the observation group was significantly superior to that of the control group,and the difference was statistically significant(P＜0.05).(2)After treatment,the levels of ALT,AST and GGT in the two groups were significantly lower than those before treatment(P＜0.05),and the decrease of ALT,AST and GGT in the observation group was significantly superior to that in the control group(P＜0.05).(3)After treatment,the levels of CHOL and TRIG in the two groups were significantly lower than those before treatment(P＜0.05),and the decrease of CHOL and TRIG in the observation group was significantly superior to that in the control group(P＜0.05).(4)After treatment,the degree of hepatic steatosis in the two groups was significantly lower than that before treatment(P＜0.05),and the decrease of the degree of hepatic steatosis in the observation group was significantly superior to that in the control group(P＜0.05).(5)During the treatment,no obvious adverse reactions occurred in the two groups,indicating high safety.Conclusion The therapy of clearing heat,percolating dampness and lowering turbidity combined with Silibin Meglumine Tablets exerts certain effect in the treatment of NASH patients with abnormal ALT level of damp-heat accumulation type,and the therapy can significantly enhance the clinical efficacy of Silibin Meglumine Tablets alone for NASH.
