Effect of administration of etretinate and fish oil on plasma cholesterol levels in rats.
- Author:
Kuk Hyeong LEE
;
Do Won KIM
;
Jae Bok JUN
- Publication Type:Original Article
- Keywords:
Fish oil;
Et.retinate;
holesterol
- MeSH:
Acitretin*;
Animals;
Cholesterol*;
Etretinate*;
Plasma*;
Rats*
- From:Korean Journal of Dermatology
1991;29(2):167-173
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The authors studied the plasma cholesterol levels in 39 rats (Sprague-Dawley) after 4 weeks administration of etretinate and/or fish oil. The study groups were as follows.'13 rats recieved etretinate only;13, fish oil only;13, both ertetinate and fish oil. Cholesterol levels were determined by standard enzymatic methodology. The results were as follows. Tot,al-cholesterol levels in rats following administration of ertetinate only were increased(p<0.05), but the levels in rats receiving fish oil only and both etretinate and fish oil were markedly decreased(p<0.01). HDL-cholesterol levels in rats following administration of fish oil and both etretinate and fish oil were decreased(p<0.01). The ratio of HDL-cholesterol to total-cholesterol in rats receiving fish oil only and both etretinate and fish oil were increased(p<0.05) because of markedly decreased total-cholesterol levels.
