Effect of Huangqi Xuming Decoction on Norepinephrine,Hypersensitive C-reactive Protein,Superoxide Dismutase and Activities of Daily Living of Patients with Alzheimer's Disease of Spleen and Kidney Deficiency Type
10.13359/j.cnki.gzxbtcm.2024.06.007
- VernacularTitle:黄芪续命汤对阿尔兹海默症脾肾亏虚型患者NE、Hs-CRP、SOD及生活能力的影响
- Author:
Yan YUAN
1
;
Lu-Ling TAO
;
Ju-Kong ZHANG
Author Information
1. 河南省南阳市第二人民医院,河南南阳 473012
- Keywords:
Huangqi Xuming Decoction;
Alzheimer's disease;
spleen and kidney deficiency type;
norepinephrine(NE);
hypersensitive C-reactive protein(Hs-CRP);
superoxide dismutase(SOD);
abilities of daily living
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(6):1416-1422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of Huangqi Xuming Decoction for Alzheimer's disease(AD)patients with spleen and kidney deficiency syndrome and to explore its possible mechanism.Methods A total of 134 patients with AD of spleen and kidney deficiency type were randomly divided into observation group and control group,with 67 cases in each group.The control group was treated with routine western medicine,and the observation group was treated with Huangqi Xuming Decoction on the basis of treatment for the control group.The course of treatment for the two groups covered 12 weeks.The changes of traditional Chinese medicine(TCM)syndrome score,Mini-Mental State Examination(MMSE)score,Alzheimer's Disease Assessment Scale-Cognitive Subscale(ADAS-Cog)score and serum levels of 5-hydroxytryptamine(5-HT),norepinephrine(NE),brain-derived neurotrophic factor(BDNF),superoxide dismutase(SOD),interleukin-6(IL-6)and hypersensitive C-reactive protein(Hs-CRP)in the two groups before and after treatment were observed.After treatment,the clinical efficacy of the two groups was evaluated.Results(1)After 12 weeks of treatment,the total effective rate of the observation group was 89.55％(60/67)and that of the control group was 71.64％(48/67),and the intergroup comparison(tested by chi-square test)showed that the efficacy of the observation group was significantly superior to that of the control group(P＜0.05).(2)After treatment,the MMSE scores of the patients in the two groups were higher(P＜0.05)and the TCM syndrome scores and ADAS-Cog scores were lower than those before treatment(P＜0.05).The intergroup comparison showed that the increase of the MMSE scores and the decrease of the TCM syndrome scores and ADAS-Cog scores in the observation group were significantly superior to those in the control group(P＜0.05).(3)After treatment,the serum 5-HT,NE,BDNF,and SOD levels of the two groups were higher(P＜0.05)and serum IL-6 and Hs-CRP levels were lower than those before treatment(P＜0.05).The intergroup comparison showed that the increase of serum 5-HT,NE,BDNF,and SOD levels and the decrease of serum IL-6 and Hs-CRP levels in the observation group were significantly superior to those in the control group(P＜0.05).Conclusion For patients with AD of spleen and kidney deficiency type,the application of Huangqi Xuming Decoction based on the conventional western medicine treatment is helpful to relieving the inflammatory response,regulating the imbalance of oxidative stress,promoting the improvement of the patients'abilities of daily living,and enhancing the clinical efficacy.
