Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma
10.1016/j.livres.2020.11.001
- Author:
Setayesh TAHEREH
1
;
D.Colquhoun STEVEN
;
Wan Yvonne YU-JUI
Author Information
1. Department of Pathology and Laboratory Medicine
- Keywords:
Galectin-1(Gal-1);
Galectin-3(Gal-3);
Liver cancer;
Hepatocellular carcinoma(HCC);
Fibrosis;
Cirrhosis;
Non-alcoholic steatohepatitis(NASH);
Metastasis;
Epithelial-mesenchymal transition(EMT)
- From:
Liver Research
2020;4(4):173-179
- CountryChina
- Language:Chinese
-
Abstract:
Galectins(Gals)are evolutionarily conserved proteins that bind to β-galactoside containing glycans.Abnormal expression of Gals is associated with the development,progression,and metastasis of different types of cancer.Among the 11 Gals identified in humans,the roles of Gal-1 and Gal-3 have been extensively investigated in various tumors.Here,we summarize the roles of overly expressed Gal-1 and Gal-3 in the pathogenesis of hepatocellular carcinoma(HCC).The overexpression of Gal-1 and Gal-3 correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,and poor prognosis.A potentially promising future treatment strategy for HCC may include the combination of immunotherapy with Gal-1 inhibition.Additional research is warranted to investigate targeting Gal-1 and Gal-3 for HCC treatment.
