Platelets:A review of their function and effects in liver diseases
10.1016/j.livres.2020.08.002
- Author:
Chen HAOQI
1
;
Chen XIAOLONG
;
Wang GENSHU
Author Information
1. Department of Hepatic Surgery
- Keywords:
Platelets;
Hepatic fibrosis;
Hepatic ischemia-reperfusion injury;
Liver regeneration;
Liver diseases
- From:
Liver Research
2020;4(3):129-135
- CountryChina
- Language:Chinese
-
Abstract:
Platelets are small fragments of the cytoplasm and are detached from the cytoplasm of mature mega-karyocytes.They play an important role in the function of blood coagulation in humans.Recent studies have shown that in addition to participating in hemostasis,platelets play a critical role in liver regen-eration,liver inflammation,liver tumors,injury,and other liver diseases by regulating the activation of stellate cells and the interaction between Kupffer cells and sinusoidal endothelial cells.Targeting platelets and their related molecules is a promising treatment strategy in the management of liver diseases.Here,we review the role of platelets and their related molecules in the development of liver diseases and the application of targeted drugs.
