B lymphocyte-mediated humoral immunity in the pathogenesis of chronic hepatitis B infection
10.1016/j.livres.2020.07.001
- Author:
Pan JING
1
;
Yao TIANTIAN
;
Cheng HAO
;
Zhu YAN
;
Wang YAN
Author Information
1. Department of Infectious Diseases
- Keywords:
Hepatitis B virus(HBV);
Humoral immunity;
HBV-specific B cell;
Atypical memory B cell;
Cytokines
- From:
Liver Research
2020;4(3):124-128
- CountryChina
- Language:Chinese
-
Abstract:
During hepatitis B virus(HBV)infection,the host immune response,including the presence of functional HBV-specific T cells and HBV-specific antibody-producing B cells,ultimately determines the HBV infection outcome:either the virus is cleared,or infection persists.Functional exhaustion of HBV-specific CD8+cytotoxic T cells is the most important immune feature in chronic HBV infection.However,chronic HBV infection also re-writes humoral immunity,whereby B cells are the leading participants.In this review,we highlight HBV-specific B cell responses and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies.
