Nuclear receptors and non-alcoholic fatty liver disease:An update
10.1016/j.livres.2020.03.001
- Author:
Yang XIAO
1
;
J.Gonzalez FRANK
;
Huang MIN
;
Bi HUICHANG
Author Information
1. Guangdong Provincial Key Laboratory of New Drug Design and Evaluation
- Keywords:
Nuclear receptors(NRs);
Non-alcoholic fatty liver disease(NAFLD);
Pregnane X receptor(PXR);
Constitutive androstane receptor(CAR);
Farnesoid X receptor(FXR);
Peroxisome proliferator activated receptor(PPAR);
Liver X receptor(LXR)
- From:
Liver Research
2020;4(2):88-93
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease(NAFLD)has become the leading cause of chronic liver disease in adults and children worldwide.The symptoms of NAFLD range from simple steatosis and non-alcoholic stea-tohepatitis(NASH)to hepatic fibrosis or cirrhosis,even ultimately develops to hepatocellular carcinoma.Nuclear receptors(NRs)are a superfamily of ligand-activated transcription factors,most of which are ligand-activated that control cellular homeostasis in the liver and other tissues.A growing number of studies demonstrated the important role of NRs in NAFLD.In this review,the current findings on the role of NRs in NAFLD are summarized and future perspectives to target NRs for NAFLD are discussed.
