Necroptosis in ischemia-reperfusion injury of lean and steatotic livers
10.1016/j.livres.2019.09.003
- Author:
Sun HUA
1
;
McKeen TARA
;
Wang HUA
;
Ni HONG-MIN
Author Information
1. Department of Pharmacology
- Keywords:
Necroptosis;
Non-alcoholic fatty liver disease(NAFLD);
Alcoholic liver disease(ALD);
Ischemia-reperfusion(IR);
Liver injury
- From:
Liver Research
2019;3(3):227-233
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic ischemia-reperfusion(IR)injury is a major complication during liver transplantation,liver resection,and other clinical situations.Increased hepatic IR injury in steatotic livers is a major reason for rejecting the use of steatotic livers for liver transplantation.Necroptosis is implicated in the pathogenesis of fatty liver diseases,including non-alcoholic fatty liver disease(NAFLD)and alcoholic liver disease(ALD).Necroptosis is one type of regulated cell death and is regulated by three key proteins:receptor-interacting protein 1(RIP1),receptor-interacting protein 3(RIP3),and mixed-lineage kinase domain-like protein(MLKL).In this review,we examine the necroptosis status in the steatotic liver diseases NAFLD and ALD as well as its role in hepatic IR injury of lean and steatotic livers.
