Lipid droplet dynamics in alcoholic fatty liver disease
10.1016/j.livres.2019.09.002
- Author:
J.Schulze RYAN
1
;
Ding WEN-XING
Author Information
1. Department of Biochemistry and Molecular Biology and the Division of Gastroenterology and Hepatology
- Keywords:
Lipid droplet(LD);
Alcohol;
Autophagy;
Lipolysis;
Hepatocyte;
Steatosis
- From:
Liver Research
2019;3(3):185-190
- CountryChina
- Language:Chinese
-
Abstract:
The rising incidence of alcohol-related liver disease(ALD)demands making urgent progress in under-standing the fundamental molecular basis of alcohol-related hepatocellular damage.One of the key early events accompanying chronic alcohol usage is the accumulation of lipid droplets(LDs)in the hepato-cellular cytoplasm.LDs are far from inert sites of neutral lipid storage;rather,they represent key or-ganelles that play vital roles in the metabolic state of the cell.In this review,we will examine the biology of these structures and outline recent efforts being made to understand the effects of alcohol exposure on the biogenesis,catabolism,and motility of LDs and how their dynamic nature is perturbed in the context of ALD.
