The interplay between hepatocyte nuclear factor 4α(HNF4α)and cholesterol sulfotransferase(SULT2B1b)in hepatic energy homeostasis
10.1016/j.livres.2019.09.004
- Author:
Bi YUHAN
1
;
Wang YOUYA
;
Xie WEN
Author Information
1. Center for Pharmacogenetics
- Keywords:
Nuclear receptor;
Hepatocyte nuclear factor 4alpha(HNF4α);
Sulfotransferase(SULT);
Cholesterol sulfotransferase 2B1b;
(SULT2B1b);
Energy homeostasis
- From:
Liver Research
2019;3(3):143-149
- CountryChina
- Language:Chinese
-
Abstract:
The nuclear receptor hepatocyte nuclear factor 4alpha(HNF4α)plays a critical role in the regulation of metabolic homeostasis,including glucose homeostasis.Sulfotransferases(SULTs)catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate(PAPS)to an acceptor molecule.Sulfonation plays an essential role in regulating the chemical and functional homeostasis of endogenous and exogenous molecules.Among SULTs,the cholesterol sulfotransferase 2B1b(SULT2B1b)preferentially catalyzes the sulfoconjugation of cholesterol and oxysterols to form cholesterol sulfate and oxysterol sulfates.Hepatic gluconeogenesis represents a critical component of energy metabolism.Although there have been reviews on the regulation of glucose homeostasis by HNF4α,the interplay between HNF4α and SULT2B1b in hepatic glucose homeostasis remains scattered.In this review,we intend to provide an overview on how HNF4α functionally cross-talks with SULT2B1b to regulate hepatic glucose homeostasis and whether the HNF4α-SULT2B1b axis represents a novel therapeutic target for the management of metabolic liver disease and metabolic syndrome.
