Role of gut microbiota in the development of non-alcoholic fatty liver disease
10.1016/j.livres.2019.01.006
- Author:
Wang XUEMEI
1
;
Xia JIALIN
;
Jiang CHANGTAO
Author Information
1. Department of Physiology and Pathophysiology
- Keywords:
Non-alcoholic fatty liver disease(NAFLD);
Gut microbiota;
Bile acid;
Farnesoid X receptor(FXR);
Ceramide;
Bile salt hydrolase(BSH)
- From:
Liver Research
2019;3(1):25-30
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease(NAFLD)is a chronic liver disease characterized by hepatic steatosis in the absence of other causes,such as chronic alcohol consumption,that cause secondary hepatic fat accumulation.NAFLD has become the most common liver disease worldwide over the past two decades,and the prevalence of NAFLD is 20-30％in Western countries.However,the mechanism of NAFLD re-mains unclear.The gut microbiota plays an important role in the metabolism of the host;in fact,it has been implicated in inflammatory diseases,metabolic syndrome and cardiovascular disease.Accumu-lating evidence has indicated that gut microbiota component changes are linked to human obesity,in-sulin resistance(IR),type 2 diabetes and NAFLD.Here,we provide insight into the role of gut microbiota,especially bile salt hydrolase(BSH)in modulating the bile acid pool and farnesoid X receptor(FXR),which promotes the synthesis of ceramide and contributes to the development of NAFLD.
