Tumor-suppressing effects of autophagy on hepatocellular carcinoma
10.1016/j.livres.2018.08.001
- Author:
Pang LIJUN
1
;
Liu KAI
Author Information
1. Capital Medical University Affiliated Beijing YouAn Hospital
- Keywords:
Autophagy;
Mitophagy;
Cell death;
Hepatocellular carcinoma(HCC);
Damage-regulated autophagy modulator(DRAM)
- From:
Liver Research
2018;2(3):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Evasion of apoptosis is one of the hallmarks of hepatocellular carcinoma(HCC)that results in treatment resistance.Recently,autophagy was reported to induce cell death in HCC,highlighting the tumor-suppressing effects of autophagy on HCC.This review summarizes our current understanding of the HCC-suppressing effects of macroautophagy(hereafter referred to as autophagy)to provide insights into the molecular mechanisms that may be essential for the development of autophagy-targeting thera-peutic strategies for HCC.
