Autophagy in ischemic aged livers
10.1016/j.livres.2018.09.006
- Author:
Lee CHOONGHEE
1
;
Kim JAE-SUNG
Author Information
1. Department of Surgery
- Keywords:
Hepatocytes;
Autophagy;
Mitochondrial autophagy(mitophagy);
Aging;
Ischemia/reperfusion(I/R);
Sirtuin 1-mitofusin 2(SIRT1-MFN2)axis
- From:
Liver Research
2018;2(3):133-137
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia/reperfusion(I/R)injury inevitably occurs during liver resection and transplantation.Elderly patients poorly recover from these surgeries.This reduced reparative capacity with aging is causatively associated with decreased mitochondrial function after reperfusion.Mitochondrial autophagy(mitophagy)is a vital cellular process that timely clears abnormal and dysfunctional mitochondria.Impaired or insufficient autophagy can contribute to hepatocyte death after I/R.This review describes our current understanding of I/R injury and highlights new mechanistic correlation between sirtuin 1(SIRT1),mitofusin 2(MFN2),and autophagy in the pathogenesis of age-dependent hypersensitivity to reperfusion injury.The deacetylation of MFN2 by SIRT1 plays a pivotal role in the recovery from reperfusion injury by modulating the onset of autophagy.Targeting the SIRT1-MFN2 axis could be a new therapeutic target to reduce I/R injury in aged livers.
