Effects of Sodium Citrate on Salt Sensitivity and Kidney Injury in Chronic Renal Failure.
10.3346/jkms.2014.29.12.1658
- Author:
Sejoong KIM
1
;
Jin Young YANG
;
Eun Sook JUNG
;
Jeonghwan LEE
;
Nam Ju HEO
;
Jae Wook LEE
;
Ki Young NA
;
Jin Suk HAN
Author Information
1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Kidney Failure, Chronic;
Citrates;
Acidosis;
Natriuresis
- MeSH:
Acute Kidney Injury/diagnosis/*drug therapy/*physiopathology;
Administration, Oral;
Animals;
Citrates/*administration & dosage;
*Dietary Supplements;
Kidney Failure, Chronic/*diet therapy/*physiopathology;
Male;
Rats;
Rats, Sprague-Dawley;
Salt-Tolerance/*drug effects;
Treatment Outcome
- From:Journal of Korean Medical Science
2014;29(12):1658-1664
- CountryRepublic of Korea
- Language:English
-
Abstract:
Metabolic acidosis, which is observed in salt-sensitive hypertension, is also associated with kidney injury. Alkali therapy in chronic renal failure (CRF) may ameliorate the progression of kidney disease; however, few studies have examined the effects of alkali therapy on salt sensitivity and kidney injury in CRF. We randomly administered standard diet (SD), sodium chloride with 20% casein diet (NACL), or sodium citrate with 20% casein diet (NACT) to Sprague-Dawley rats after a CRF or a sham operation. Four weeks after 5/6 nephrectomy, serum bicarbonate levels were higher in the NACT-treated group. On the pressure-natriuresis curve, NACT-treated CRF rats were more salt-resistant than NACL-treated CRF rats. Additionally, the NACT-treated CRF group showed less tubulointerstitial damage than the NACL-treated CRF group. The expression and immunoreactivity of NHE3 in the kidney in the NACT-treated CRF group were lower than those in the NACL-treated CRF group. We observed that dietary NACT as alkali therapy in CRF might improve the altered salt-sensitivity and ameliorate the progression of kidney injury compared to the NACL diet, which may be related to reduced renal NHE3 expression.
