Roles of microRNA in liver cancer
10.1016/j.livres.2018.06.002
- Author:
Tao JUNYAN
1
;
Jiang LILI
;
Chen XIN
Author Information
1. Department of Pathology
- Keywords:
MicroRNAs(miRNAs);
Liver cancer;
Hepatocellular carcinoma(HCC);
Cholangiocarcinoma(CCA);
Hepatoblastoma(HB);
Diagnosis;
Therapy
- From:
Liver Research
2018;2(2):61-72
- CountryChina
- Language:Chinese
-
Abstract:
Primary liver cancer is the fifth most common cancer and the third leading cause of cancer death worldwide.MicroRNAs(miRNAs)are small non-coding RNA molecules that downregulate gene expression by binding to the 3'-untranslated region of target miRNAs.MiRNAs function as tumor sup-pressors or oncogenes by regulating oncogene or tumor suppressor gene expression and their related signaling pathways involved in liver cancers including hepatocellular carcinoma,cholangiocarcinoma,and hepatoblastoma.In this review,we provide a systematic evaluation of the relationship between miRNAs and liver cancers,and describe the potential applications of miRNAs in liver cancer diagnosis and treatment.
