O-glycosylation in liver cancer:Clinical associations and potential mechanisms
10.1016/j.livres.2017.12.005
- Author:
Liang KUNG-HAO
1
;
Yeh CHAU-TING
Author Information
1. Liver Research Center
- Keywords:
O-glycosylation;
Post-translational modification;
Glycobiology;
Biomarkers;
Hepatocellular carcinoma(HCC);
Glycosyltransferase
- From:
Liver Research
2017;1(4):193-196
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer can be an aggressive disease,and is highly prevalent in Asia and Africa.However,its currently approved therapeutic strategies are far from satisfactory.Recent progress in genomic,prote-omic and glycomic profiling technologies have enabled the identification of biomarkers that significantly correlate with clinical outcomes.Many biomarkers are related to O-glycosylation of glycoproteins,which belong to an important but less-explored field of liver cancer biology.Here,we review these clinical studies and discuss potential underlying mechanisms.
