Long non-coding RNA in liver metabolism and disease:Current status
10.1016/j.livres.2017.09.001
- Author:
Zhao YULAN
1
;
Wu JIANGUO
;
Liangpunsakul SUTHAT
;
Wang LI
Author Information
1. Department of Physiology and Neurobiology
- Keywords:
Long non-coding RNA(lncRNA);
Liver;
Lipid metabolism;
Glucose metabolism;
Cholestatic liver disease
- From:
Liver Research
2017;1(3):163-167
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs(lncRNAs)are comprised of RNA transcripts exceeding 200 nucleotides in length but lacking identifiable open reading frames(with rare exceptions).Herein,we highlight emerging ev-idence demonstrating that lncRNAs are critical regulators of liver metabolic function and diseases.We summarize current knowledges about dysregulated lncRNAs and outline the underlying molecular mechanisms by which lncRNAs control hepatic lipid ad glucose metabolism,as well as cholestatic liver disease.Liver-specific triglyceride regulator(lncLSTR),Lnc18q22.2,steroid RNA activator(SRA),highly upregulated in liver cancer(HULC),metastasis associated in lung adenocarcinoma transcript 1(MALAT1),liver glucokinase repressor(lncLGR),maternally expressed gene 3(MEG3),and H19,lncHR1,lnc-HC,apolipoprotein A1 antisense transcript(APOA1-AS),DYNLRB2-2,and LXR-induced sequence(LeXis)are included in the discussion.
