Mesenchymal stem cells for treatment of steroid-resistant acute rejection after liver transplantation
10.1016/j.livres.2017.07.001
- Author:
Zhang YINGCAI
1
;
Li SHIHUI
;
Wang GUOYING
;
Peng YANWEN
;
Zhang QI
;
Li HUA
;
Zhang JIAN
;
Wang GENSHU
;
Yi SHUHONG
;
Chen XIAOYONG
;
Xiang Peng ANDY
;
Yang YANG
;
Chen GUIHUA
Author Information
1. Department of Hepatic Surgery
- Keywords:
Mesenchymal stem cells(MSCs);
Liver transplantation(LT);
Steroid-resistant acute rejection;
Immunoregulation
- From:
Liver Research
2017;1(2):140-145
- CountryChina
- Language:Chinese
-
Abstract:
A patient with steroid-resistant acute rejection 50 days after ABO-compatible orthotopic liver trans-plantation(LT)received regular infusion of allogeneic mesenchymal stem cells(MSCs)after three ses-sions of steroid pulse therapy which failed to control the pathogenetic condition as shown by biopsy.Liver function improved gradually after intravenous injection of MSCs once weekly for 10 weeks(as confirmed by biopsy)and remained stable under administration of conventional immunosuppressive agents.There was no evidence of neoplasms 5 years after treatment.MSCs infusion appears to suc-cessfully reverse resistance to immunosuppressive agents and may be a useful treatment for post-liver transplant steroid-resistant rejection.
